Developed by operators. Structured for pressure. Built so your decisions hold when time is short and error is costly.
Pilots have checklists. Surgeons have protocols. SEAL teams have SOPs. The Two Risks framework separates Elephant Risk from Structural Risk. You build your own structural management binder as you progress.
Chris and Christos personally facilitate every evolution — live cohort sessions every two weeks, led by the co-founders themselves. Not recorded. What you ask stays in the room. Core-evolution cohorts are multi-disciplinary and international; peer learning is built into the design. Cohorts and graduates reconvene in person semi-annually.
Built by a serial entrepreneur with multiple exits, including the $5.75 billion acquisition of Auris Health by Johnson & Johnson, and a legal and business scholar with multiple advanced degrees in international law and business administration. Guided by an advisory committee of leading venture capitalists, M&A specialists, corporate attorneys, behavioral scientists, and strategists.
Regulatory pathways. Reimbursement coding. IP licensing from academic medical centers. Clinical development capital requirements. Pharma partnering dynamics. Sixteen evolutions, nine healthcare-specific.
VCs negotiate hundreds of deals. Founders negotiate a handful. The terms you sign determine what you keep. This is the knowledge your investors already have.
Not competing with MBAs, accelerators, or incubators. Sequential, not substitutional. The structural mechanics that determine who keeps what they built.
Everything between your innovation and your outcome.
The governance traps, the capital structure landmines, the deal mechanics that transfer value away from the people who created it — these are not bad luck. They are predictable. And they are preventable.
Not because the science failed. Because the business did.
You have spent years developing expertise. You have seen the gap between what is possible in research and what is available in practice. You may have an idea, a device concept, a protocol that could change outcomes for your patients.
Without specific translational training, the data says you have roughly a 10 to 25 percent chance of getting it to market. Not because your science is not good enough. Because the translational process is a discipline unto itself, and almost no one teaches it.
Your institution is investing millions in research and innovation. Your faculty are generating intellectual property. Your residents have ideas.
Without structured translational training, 75 to 90 percent of those investments will produce zero patient impact and zero financial return. That is not a research problem. It is a management problem. And it is solvable.
Surgery was once barbarism. Unsterile, agonizing, frequently fatal. It was not transformed by a single genius. It was transformed by systems: antiseptic protocols, standardized training, checklists, peer review.
The same transformation has not happened for healthcare entrepreneurship.
We built it.
Long before AEIOU Academy existed, Chris helped me navigate the complexity of building and scaling companies with clarity, discipline, and a level of rigor that protects founders from moving blindly or in the dark.
Your researchers are generating the science. We help you build the system to get it to patients.
Built by the operators who lived the failures it teaches.
Chris Velis co-founded Auris Health — acquired by Johnson & Johnson for $5.75 billion — and spent a career across every side of the entrepreneurial process: banker, investor, founder, director. With Dr. Christos Kelepouris, he drew the map most healthcare innovators never see in time.
Read the founders’ letter →